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IEEE Transactions on Biomedical Engineering, November 2016







Steering of Magnetic Devices using a Magnetic Particle Imaging System

N.‎ Nothnagel, J.‎ Rahmer, B.‎ Gleich, A.‎ Halkola, T.M.‎ Buzug, J.‎ Borgert, University of Lübeck, Philips Technologie GmbH, Germany,  Volume 63, Issue 11, Page: 2286-2293 

Magnetic manipulation is a promising approach that enables contact-free manipulation of devices inside a patient.‎ By
controlling magnetic forces, new medical applications become possible such as magnetically guided catheters or magnetic steering of camera pills.‎ A newly developed magnetic particle imaging (MPI) system combines fast imaging with a flexible and powerful field applicator.‎ This work demonstrates that it is therefore well suited for controlled steering of small magnetic devices.‎ Experimental evidence is presented on steering a prototype device in arbitrary direction and with variable force under real-time imaging control.‎   Read More
Fast Electromagnetic Analysis of MRI Transmit RF Coils based on Accelerated Integral Equation Methods
Jorge Fernández Villena, Athanasios G.‎ Polimeridis, Yigitcan Eryaman, Elfar Adalsteinsson, Lawrence L.‎ Wald, Jacob K.‎ White, and Luca Daniel, 

 Massachusetts Institute of Technology, University of Minnesota, Massachusetts General Hospital, Harvard-MIT Division of Health Sciences Technology, USA,  Volume 63, Issue 11, Page: 2250-2261  

This work combines the integral equation method with sophisticated numerical techniques, and the newly introduced magnetic resonance Green functions, into an efficient full-wave frequency-domain simulation tool for the analysis of interactions between electromagnetic waves created by arbitrary RF coils and realistic human body models, including the virtual family population.‎ The novel algorithms are incorporated into the open-source software MARIE, allowing it to characterize complex MRI designs within few minutes, including the computation of the un-tuned coil port parameters, the current distribution for the tuned coils, and the corresponding electromagnetic fields distribution in the inhomogeneous body.‎ Read More

One-Day Bayesian Cloning of Type 1 Diabetes Subjects: Towards a Single-Day UVA/Padova Type 1 Diabetes Simulator

Roberto Visentin, Chiara Dalla Man, and Claudio Cobelli, University of Padova, Italy,   Volume 63, Issue 11, Page: 2416-2424

 We propose a Bayesian method for generating an in silico clone that resembles the physiological behavior of a type 1 diabetic subject (T1DM).‎ The method is based on the Universities of Virginia/Padova T1DM Simulator.‎ In particular, we identified the model included in the simulator from 24-hour plasma glucose and insulin concentrations with a Bayesian technique that used, as prior, the model parameter distribution of the simulator.‎ Diurnal variability of subject's insulin sensitivity and meal glucose absorption was also allowed.‎ Cloning a T1DM individual allows to move towards a personalized treatment.‎ Read More

Scattering and Diffraction of Elastodynamic Waves in a Concentric Cylindrical Phantom for MR Elastography



Benjamin L.‎ Schwartz, Ziying Yin, Temel K.‎ Yasar, Yifei Liu, Altaf A.‎ Khan, Allen Q.‎ Ye, Thomas J.‎ Royston, and Richard L.‎ Magin, University of Illinois, USA 


Volume 63, Issue 11, Page: 2308-2316

Presented here is a dynamic analysis of a multiply connected body for magnetic resonance elastography.‎  We derive, from first principles, the closed form solution to a concentric cylindrical body undergoing harmonic oscillations.‎ We then describe the phantom construction, experimental procedure, parameter estimation, and the forward problem.‎ To validate our model, we use the shear moduli estimates as inputs to solve the forward problem with a finite-element model (FEM) and compare that with experimental results.‎ Finally we consider the immediate consequences of this work as well its implications for future research.‎